This blog discusses the ingredients of Alz-Halt AB. Leafyceuticals
supplements are made to oppose the symptoms of Alzheimer’s Disease (AD). The
information below describes the action of Leafyceutical’s “Advanced Blend” components on Alzheimer’s processes.
People over 40 begin to display the same changes in their brains as Alzheimer’s
victims. Thus, the Alz-Halt AB supplement should help anyone preserve their memory,
clarity, and cognitive functions. It may also help others who may have post-Covid brain
fog or other mental losses.
“AlzHalt AB” contains an Advanced Blend of components, each of which has been
studied and the results published in scientific journals. The components include: Lion’s Mane, Poria cocos, Hesperidin, Broccoli Powder (sulforaphane), Fucoidan, Berberine,
Spermidine, Taurine and Piperine. The review below describes the benefits from each
element. The mixture seeks to provide a combined effect where consuming different
molecules act together to suppress various processes leading to Alzheimer's Disease.
In general, these components help brain function and preserve recall.
Piperine
Piperine, an alkaloid in black pepper, has anti-inflammatory, antioxidant, neuronal
transmission, antidepressant and antipyretic effects. Piperine can enhance the effects of
other active molecules and has antimicrobial, and anti-ulcer benefits.
Taurine
Taurine occurs naturally in the body and comes in meat, fish, and eggs. Taurine has
important functions in the heart and brain, and helps support nerve growth. Taurine has
been shown to protect mitochondria (cell energy producers) and prevent the death of
neurons caused by amyloid beta and oxidative stress. Taurine also inhibits the
aggregation of amyloid proteins into plaques. 1
Spermidine
The healthy body both produces spermidine and absorbs spermidine from foods: aged
cheese, mushrooms, soy products, legumes, corn, and whole grains.
Subjects with mild dementia who took spermidine showed improved test performance
compared to those with lower spermidine intake. Spermidine treatment significantly
increased Aβ degradation and reduced soluble Aβ levels in vivo. Spermidine enhances
Aβ removal and counteracts glia-mediated neuroinflammation by reducing the release of inflammatory hormones (cytokines). Spermidine also prevented AD associated
cytoskeletal changes. 2,3
Berberine
Berberine, a bitter-tasting molecule, can be extracted from roots or stem bark of many
plants. Berberine inhibits AD by preserving the α-secretase degradation of Amyloid
Precursor Protein (APP) over beta-secretase (BACE-1). Cleavage of APP by BACE-1
produces amyloid plaque. Berberine also inhibits oxidation in mitochondria and thus
short-circuits the Alzheimer’s oxidation/inflammation spiral. Berberine reduces the
production of tau proteins and thus reduces neurofibrillary tangles (NFTs). 4
Berberine can reduce cognitive impairment by increasing glutathione activity. Berberine
also activates a nuclear receptor which then reduces inflammatory cytokines. Lastly,
berberine may aid the regeneration of neuronal processes. 5
Fucoidan
Fucoidan, extracted from brown algae, is a complex sulfated polysaccharide.
Fucoidan inhibits the activation of inflammatory caspases while preventing the death of
neurons (apoptosis). Fucoidan activates antioxidant enzymes and increased glutathione
levels, shifting brain biochemistry away from inflammation. While Aβ exposure
increased reactive oxidative species (ROS), lipid peroxidation and mitochondrial ROS,
fucoidan suppressed these changes. Polysaccharides like Fucoidan readily cross the
blood brain barrier (BBB) to express their neuroprotective effects. Fucoidan reverses
amyloid-induced decrease in cell viability. Fucoidan has been reported to moderate lipid
levels, arteriosclerosis and cancer. 6
Sulforaphane (Broccoli powder)
Cruciferous vegetables provide a source of Sulforaphane, a molecule that promotes
detoxifying, anti-oxidation, and immune system-modulating enzymes. Sulforaphane
promotes enzymes such as NAD(P)H and glutathione S-transferases. The activity of
these enzymes overlaps their suppression of cancer by clearing carcinogens.
Sulforaphane studies show it protects neurons and microglia against oxidative stress.
Sulforaphane has been found to prevent Aβ production, again by decreasing the
expression of β-secretase (BACE1) which makes amyloid protein. The amyloid protein
that does get produced is less likely to aggregate into plaque. Sulforaphane treatment
also decreased levels of toxic cytokines and the COX-2 enzyme that produces oxidative
stress.
Sulforaphane has shown anti-AD activity in a dozen animals and cell lines.
Sulforaphane increased signaling pathways that enhance synaptic plasticity and
improved cognitive function in AD-like animal models. 7
Hesperidin
Hesperidin, a bioflavonoid found in citrus plants, has anti-inflammatory, antioxidant, and neuroprotective effects. Hesperidin is lipophilic and can easily cross the blood-brain
barrier. Hesperidin benefits include fighting cancer, balancing lipid levels and helping
with hypertension. In AD-models, Hesperidin improved spatial learning and memory,
spatial memory, long-term memory, and recognition memory. Diets supplemented with
hesperidin improved cerebral blood flow, cognitive function and memory performance. 9
Hesperidin restored neuron growth in the brains of an AD experiment (via
AMPK/BDNF/CREB signaling) thereby decreasing amyloid-beta accumulation. By
activating AMPK, Hesperidin boosted a signal crucial to neurogenesis. Neural Stem
Cells proliferated following treatment with Hesperidin, and the changes were believed to
have protected memory formation. (AMPK=AMP-activated protein kinase) 8
Poria cocos
Studies of Poria cocos have found that it can reduce signaling of the MAPK/NF-κB
pathway. The decreased activity of these proteins helps cell growth, cell survival,
immune and inflammatory responses, and development. 10 Poria cocos inhibited the
activity of caspase-3 and oxidation products that worsen Alzheimer’s processes. 12
In other research: “Mice treated with Poria cocos showed significant improvements in
cognitive function as evaluated by the behavioral experiment.” And “Treatment relieved
Aβ deposition by reducing the formation of Aβ and increasing its clearance.” 11
Lion's Mane
Lion’s Mane grows on old hardwood (oak, walnut, beech) producing a white ‘hairy’ mass
or fluffy ball. Alzheimer’s Drug Discovery Foundation found that Lion’s Mane displayed
antibiotic, anti-inflammatory, anti-carcinogenic, and neuroprotective properties.
Treatment with Lion’s Mane decreased amyloid plaque burden and promoted
expression of an enzyme that increased active nerve growth factor (NGF). In
Alzheimer’s Disease, the mitochondrial membranes become depolarized and calcium
leaks in. Lion’s Mane prevents this condition and, in the process, reduces toxic
oxidation caused by amyloid proteins. 13
Lion’s Mane also aided depression, anxiety, palpitation and nootropic effects. Research
has revealed that Lion’s Mane both decreased amyloid plaque aggregation and reduced
the tau tangles that kill neurons. Testing demonstrated treatment prevented cognitive
deficits in animal models of AD. 14
SUMMARY
People over 40 begin to display the same changes in their brains as Alzheimer’s
Disease (AD) victims. We formulated the Alz-Halt capsules to oppose the shifts in brain
chemistry that cause AD. These compounds restore neuronal vitality including
developing new dendritic connections. These capsules should help anyone preserve
their memory, clarity, and cognitive functions.
If one has other inflammatory conditions, the Alz-Halt FG and/or Alz-Halt CP should be
used. Inflammatory conditions include arthritis, pre-diabetes, being overweight, muscle
soreness, alcohol use, and low energy. Alz-Halt HG will help with anxiety, depression,
allergies, and Irritable Bowel Syndrome (IBS). Leafyceuticals recommends the use of all
Alz-Halt formulations at the same time. \\\
References
1. Aamer, Hira, et. al., Exploring Taurine's Potential in Alzheimer’s Treatment: A Comprehensive Review, Cureus 16(5): e60997. https://pmc.ncbi.nlm.nih.gov/articles/PMC11193974
2. Freitag, Klara, et. al., Spermidine reduces neuroinflammation and soluble amyloid beta in an Alzheimer’s disease mouse model, . Journal of Neuroinflammation 19:172, 2022., https://jneuroinflammation.biomedcentral.com/articles/10.1186/s12974-022-02534-7
3. Freitag, Klara, et. al., Spermidine reduces neuroinflammation and soluble amyloid beta in an Alzheimer's disease mouse model, J Neuroinflammation. 2022 Jul 2;19(1):172. https://pubmed.ncbi.nlm.nih.gov/35780157/
4. Cai, Zhiyou, et. al., Role of berberine in Alzheimer’s disease, Neuropsychiatric Disease and Treatment Oct. 3, 2016, https://pmc.ncbi.nlm.nih.gov/articles/PMC5055107
5. Cheng, Ziqian, et. al., Berberine: A Promising Treatment for Neurodegenerative Diseases, Frontiers in Pharmacology,13:845591, https://pmc.ncbi.nlm.nih.gov/articles/PMC9164284/
6. Nagata, Miki, et. al., Protective Effects of the Alga Fucoidan Against Amyloid-β-Induced Neurotoxicity in SH-SY5Y Cells. BPB Reports 4, 206-213, 2021, https://www.jstage.jst.go.jp/article/bpbreports/4/6/4_206/_html/-char/en
7. Kim, Jiyoung, Pre-Clinical Neuroprotective Evidence and Plausible Mechanisms of Sulforaphane in Alzheimer's Disease, Int J Mol Sci 2021 Mar 13;22(6):2929., https://pubmed.ncbi.nlm.nih.gov/33805772/
8. Lee, Danbi, et. al., Hesperidin Improves Memory Function by Enhancing Neurogenesis in a Mouse Model of Alzheimer's Disease, Nutrients 2022 Jul 29;14(15):3125,
9. Olashinde, Tosin A., et. al., The Impact of Hesperidin on Cognitive Deficit and Neurobehavioural Disorders: A Systematic Review and Meta-Analysis of Preclinical Individual Studies, Current Behavioral Neuroscience Reports (2024) 11:246–259, https://www.researchgate.net/publication/383460056
10. Xibin, Zhou, et. al., Poria cocos polysaccharide attenuates damage of nervus in Alzheimer’s disease rat model induced by D-galactose and aluminum trichloride, NeuroReport 32(8):p 727-737, May 19, 2021. https://pubmed.ncbi.nlm.nih.gov/33913927/
11. Sun, Yufei, et. al., Poria cocos could ameliorate cognitive dysfunction in APP/PS1 mice by restoring imbalance of Aβ production and clearance and gut microbiota dysbiosis, Phytother Res. 2021 May;35(5):2678-2690. https://pubmed.ncbi.nlm.nih.gov/33432644/
12. Park, Yong-Hoon, et. al., Poria cocos water extract (PCW) protects PC12 neuronal cells from beta-amyloid-induced cell death through antioxidant and antiapoptotic functions, Pharmazie 64 (2009) 11, https://www.ingentaconnect.com/content/govi/pharmaz/2009/00000064/00000011/art00011
13. The Neuroprotective Properties of Hericium erinaceus in Glutamate-Damaged Differentiated PC12 Cells and an Alzheimer’s Disease Mouse Model, Int. J. Mol. Sci. 21016, 17, 1810, https://pmc.ncbi.nlm.nih.gov/articles/PMC5133811/
14. Brandalies, Federico, et. al., Hericium erinaceus in Neurodegenerative Diseases: From Bench to Bedside and Beyond, How Far from the Shoreline?, J Fungi (Basel). 2023 May 10;9(5):551, https://pubmed.ncbi.nlm.nih.gov/37233262/
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